CELL CULTURE MEDIA

Cell Culture Media ServicesCell Culture Media Services

Custom development and GMP commercial manufacturing based on the in-house media development platform, tailored to any product and cell line.

Custom formulationsPilot manufacturingZncore® catalogMedia testingAnimal-component-free
200tonnes/year
Annual capacity
>5g/L
Average titer
15g/L
Maximum titer
<5%
Batch RSD
1.2tonnes/batch
Single-batch scale
Custom Development

Custom media developmentMedia Development

Customizing basal and feed media for mammalian cell lines and product critical quality attributes, improving glycan profiles, charge variants, fragments, oxidation and truncation.

Formulation development

Customizing basal and feed formulations for the cell line and target quality attributes.

Formulation optimization

Driven by DoE and MVA, continuously optimizing titer and product quality.

Pilot manufacturing

Pilot-scale dry powder processes ensuring seamless transfer from laboratory to production.

1
Cell line evaluation

Cell line transfer and platform evaluation.

2
Platform screening

platform media system screening.

3
Formulation optimization

basal and feed formulation optimization.

4
Bioreactor confirmation

2-5 L bioreactor verification.

5
Dry powder formulation

Dry powder formulations up to 20 L, delivering at least 80% of liquid performance.

Commercial Production

GMP commercial manufacturingGMP Manufacturing

200 tonnes/year of GMP dry powder media capacity, animal-component-free and compliance-friendly, supporting Phase III and commercial clients.

Lab scale 5-30 kg

Lab-scale batches

  • Formulation verification and process development
  • Rapid iterative delivery
Pilot scale 30-300 kg

Pilot batches

  • Process scale-up and confirmation
  • Stability study support
GMP 0.3-1 tonne

GMP batches

  • 1-1,200 kg batch scale
  • GMP + ISO 13485 systems
  • Full testing of appearance / pH / endotoxin / microbial limits, etc.
Zncore® Catalog

Zncore® catalog mediaZncore® Catalog Media

CHO platform series: basal, feed and perfusion media supporting CHO-K1, CHO-DG44, CHO-S and CHOZN.

5g/L
Average mAb titer
<5%
Batch RSD
1.2tonnes/batch
Single-batch scale
200tonnes/year
Annual capacity
View media development case studies

Media projects — leave them to Zencore

Custom development plus GMP manufacturing - the Zncore® platform builds the best-fit medium for your cell line.

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