As biologics discovery platform technologies mature, most targets now yield multiple candidate molecules with the desired functional activity. Zencore's molecular developability assessment platform provides evaluation services for post-translational modifications, molecular stability and physicochemical properties, helping clients rapidly narrow the pool of candidates early in development, select the candidates with the best activity and greatest developability, reduce downstream development risk and improve the odds of project success.
Introducing systematic developability assessment early in drug development, moving molecule selection from "activity first" to "developability first."
When multiple candidates meet activity targets for the same target, systematic evaluation quickly focuses on the superior molecule, reducing wasted investment.
Surfacing developability risks such as post-translational modifications, aggregation, fragmentation and instability early, avoiding costly rework after entering the clinic.
Delivering a developability ranking and comprehensive assessment report for candidate molecules, supporting rapid identification of the most active and most developable molecule.
From sequence-level risk identification to comprehensive molecular characterization and stress challenges, three layers build a complete developability profile.
A standardized six-step assessment pathway, from sequence analysis to a comprehensive report, providing a complete basis for candidate selection.
Systematically analyzing candidate molecule sequences to locate potential post-translational modification hotspot sites that may affect developability.
Confirming and evaluating potential sites of isomerization, deamidation, oxidation and glycosylation using experimental approaches such as mass spectrometry.
Estimating protein titer via transient transfection to rapidly prepare samples for comprehensive characterization.
mass spectrometry, SEC-HPLC, CE-SDS, CEX/iCIEF and DSF provide multi-dimensional analysis of molecular integrity, size and charge heterogeneity, and thermal stability.
Molecular stability is examined under 6 stress conditions: 40 C accelerated, light exposure, shaking, acid/base, oxidation and freeze-thaw.
Aggregating data across all dimensions to deliver a candidate developability assessment report and screening recommendations that support go/no-go decisions.
Struggling to choose among multiple candidates? Zencore's developability assessment platform helps you identify the most developable molecule early.
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